Collectively, three RPPVs described here (BRCA1 c.5096 G > A (p.Arg1699Gln), BRCA2 c.658_659del (p.Val220Ilefs*4), and BRCA2 c.8488-1 G > A) were observed in 14 ovarian tumors and five of which (35.7%) had a low (score < 42) Genomic Instability Score (GIS) and nine of which (64.3%) had a high GIS (score ≥ 42). This evidence concerns the gene BRCA2 and ovarian neoplasm.