On the contrary, CM-272 increased levels of genes related to tumor growth suppression: CPA4 (Carboxypeptidase A4), a negative regulator of the AKT/c-MYC pathway in NSCLC [33] and GNG2 (G-protein gamma subunit 2), which impairs AKT phosphorylation and cell survival [34] (Supplementary Fig. 5F). Here, CPA4 is linked to non-small cell lung carcinoma.