Blockade of G9a/DNMT1 led to alteration of several intracellular pathways in NSCLC cells, many of which affect the expression of membrane-bound proteins and extracellular signaling (such as FGF19/FGFR4, TMPRSS2, CXCL8/CXCR1-2, GNG2 and SCARA5). This evidence concerns the gene DNMT1 and non-small cell lung carcinoma.