VWF and cancer: As in the prospective study cohort, increased baseline levels of factor VIII:C (HR 1.050; confidence interval (CI) 1.019 to 1.096; p: 0.0065) and vWF ag (HR 1.031; CI 1.006 to 1.062; p: 0.0251) were also associated with an increased risk of cancer recurrence in the expanded adjuvant patient cohort (n = 20).