In conclusion, our findings suggest that reduced ability for insulin to suppress fatty acid mobilization with accompanying changes in lipid droplet size and distribution within the muscle cell, along with attenuated interaction between the insulin receptor and CD36 and Fyn in skeletal muscle, may be key contributors to the impaired insulin‐mediated glucose uptake commonly found in adults with obesity. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.