NFKB1 and cancer: In pancreatic ductal adenocarcinoma (PDAC) cells, OGA influences the regulation of NF-κB p65 subunit and the O-GlcNAcylation of IKα and IKβ, leading to the phosphorylation of p65 Ser-536 and decreased NF-κB transcriptional activity, thus promoting cancer growth [35].