For example, Ferrer et al. confirmed SIRT1's critical role in the OGT-mediated regulation of Forkhead box M1 (FOXM1) ubiquitination, showing that reducing SIRT1 activity could mitigate OGT's effects on FOXM1, thereby influencing invasion and metastasis in BC cells [151]. The gene discussed is FOXM1; the disease is breast cancer.