Tripartite motif 29 (TRIM29) triggers IGF2BP1 ubiquitination at Lys440 and Lys450 site via K48-mediated linkage, leading to protein degradation [129] and consequently enhancing PD-L1 mRNA stability and expression in 3′-UTR, which affects T-cell immunity in cancer. The gene discussed is CD274; the disease is cancer.