In addition to NF-κB, the proto-oncogene MYC has also been identified to be involved in ribosome biogenesis [45].In HCC, it is reported that colocalization of midline1 interacting protein 1 (MID1IP1) and c-Myc play a critical role in the progression of tumor through the regulation of RPL5 and RPL11 [46]. This evidence concerns the gene MYC and neoplasm.