The expression levels of these genes were comparable in A673 cells knocked out (KO) and knocked down (KD) for STAG2, and changes were also observed in two other Ewing sarcoma cell lines, SK-N-MC and A4573, upon STAG2 loss and STAG2 restoration, respectively (Figs. 2A and EV1C,D). The gene discussed is STAG2; the disease is Ewing sarcoma.