Previous studies have suggested that Ewing sarcoma cells exhibit increased replication stress and R-loop accumulation, which may be exacerbated in the absence of cohesin-STAG2 (Mondal et al, 2019; Nieto-Soler et al, 2016; Gorthi et al, 2018; Martin et al, 2022; preprint: Olmedo-Pelayo et al, 2023). Here, STAG2 is linked to Ewing sarcoma.