To reach these conclusions the authors undertook a series of preliminary experiments to create and test a population of WT and mutated diabetic animals using either the insulin or glucose tolerance test and showed that Trpc1/4/5/6–/– and Trpc5–/– mice develop an aggravated insulin-induced hypoglycemia associated with reduced plasma adrenaline. The gene discussed is TRPC5; the disease is Hypoglycemia.