A complementary pattern in the opposite direction was observed for MPV, with lower lung cancer risk for high-MPV compared to low-MPV only for low-AFI or low-ALT, and with positive additive interactions with MPV (RERI = 0.21; 95%CI: 0.03 to 0.38 for AFI; RERI = 0.19; 95%CI: 0.01 to 0.37 for ALT) (Fig. 3). This evidence concerns the gene GPT and lung cancer.