Thus, lung cancer risk was higher for high-PLT only for low-AFI or low-ALT (high-low group compared to the reference low-low group) and there were inverse additive interactions with PLT (RERI = − 0.39; 95%CI: −0.64 to − 0.13 for AFI; RERI = − 0.40; 95%CI: −0.66 to − 0.14 for ALT) (Fig. 3). This evidence concerns the gene GPT and lung carcinoma.