This hypothesis is supported by the fact that (i) macrophage-specific LAL expression in mice with global LAL-D significantly reduces CE and TG levels in the liver [50], (ii) LAL activity was decreased in hepatocytes isolated from HF/HCD-fed hepLal−/− mice, and (iii) LAL was co-expressed with CD68 in the liver of these mice. This evidence concerns the gene LIPA and hydrops fetalis.