PARK7 and peripheral neuropathy: TRPA1 could be associated with specific phenotypes observed in Dj-1−/− mice, because it is activated by cold stimuli and modulated by oxidative stress adducts, such as 4-HNE, which are known to contribute to painful peripheral neuropathy.48,49 Indeed, we demonstrated that inhibiting TRPA1 with HC030031, a widely used and highly specific TRPA1 channel blocker,50,51 reduced the cold hypersensitivity found in Dj-1−/− mice when dry ice was applied (Fig. 3D).