A recent study suggests that some of these genes indeed play a peripheral role in the prodromal symptoms of Parkinson’s disease, showing early changes in thermal sensation and peripheral neuropathy in a Parkinson’s disease mouse model lacking Pink1 and with A53T Snca mutations.13 Here, we characterize DJ-1 (encoded by the Park7 gene) as a new player controlling pain and neuropathy through its actions in peripheral sensory neurons. This evidence concerns the gene SNCA and Parkinson disease.