Similar to humans, mouse models of Parkinson’s disease have been shown to develop sensory impairments and pain that can precede motor symptoms.12 Interestingly, a recent study using a mouse model of Parkinson’s disease, which involves a loss-of-function knockin mutation of PTEN-induced kinase (Pink1), in addition to the human A53T mutation of alpha-synuclein (Scna), has shown the development of prodromal changes in thermal sensation and peripheral neuropathy.13 This evidence concerns the gene SNCA and Parkinson disease.