PARK7 and diabetic neuropathy: Methylglyoxal is generated during the hyperglycaemic states in both type 1 and 2 diabetic patients and might contribute to pain development in diabetic neuropathy.64,65 Methylglyoxal injection to Dj-1−/− mice, compared with control wild-type mice, resulted in exaggerated nocifensive behaviours and greater mechanical hypersensitivity (Supplementary Fig. 7A and B), supporting a potential role of DJ-1 in diabetic pain.