The additional OH group of kaempferol in its benzene ring might enhance its binding by filling the space between cysteine 106 and histidine 142 in DJ-1, contributing to its activity and specificity.86,87 K3OβR prevented not only the development of symptoms, but also the mechanisms associated with peripheral neuropathy, reducing oxidative stress in DRG tissue and IENF loss in the skin. The gene discussed is PARK7; the disease is peripheral neuropathy.