As previously mentioned, ND-13 is a cell-permeable peptide designed to mimic DJ-1 function,54 whereas K3OβR is a natural flavonoid known for its ability to activate DJ-1 specifically.66 We tested the effects of these compounds on paclitaxel (PAX)-induced mechanical and cold hypersensitivity, key symptoms of chemotherapy-induced peripheral neuropathy (Fig. 5A). The gene discussed is PARK7; the disease is peripheral neuropathy.