PARK7 and peripheral neuropathy: Peripheral neuropathy, although arising from diverse causes, often presents with similar symptoms and mechanisms, including inflammation and oxidative stress in DRG tissue, along with intraepidermal nerve fibre (IENF) loss in the skin.40 Transcriptional analyses of genes related to inflammation revealed no significant changes in DRG tissue from Dj-1−/− mice when compared with wild-type mice (Fig. 2A).