Interestingly, NRF2 has been linked to peripheral neuropathy and proposed as a therapeutic target for the treatment of peripheral neuropathic pain.73,74 However, it is possible that the increased oxidative stress in Dj-1−/− mice could be NRF2 independent, because DJ-1 can directly regulate mitochondrial functions and activation of multiple antioxidants, such as glutathione and superoxide dismutase.16,75 Further investigation is required to test this possibility. Here, NFE2L2 is linked to peripheral neuropathy.