Interestingly, NRF2 has been linked to peripheral neuropathy and proposed as a therapeutic target for the treatment of peripheral neuropathic pain.73,74 However, it is possible that the increased oxidative stress in Dj-1−/− mice could be NRF2 independent, because DJ-1 can directly regulate mitochondrial functions and activation of multiple antioxidants, such as glutathione and superoxide dismutase.16,75 Further investigation is required to test this possibility. This evidence concerns the gene PARK7 and peripheral neuropathy.