The enhanced tumor burden of Kras; TfamO/E mice was not mediated by the presence of an unrelated gene on the BAC clone used to overexpress TFAM because overexpressing TFAM in the Tfam+/− background (genotype: Kras; Tfam+/−; TfamO/E) resulted in a tumor burden comparable to the burden in Kras mice (fig. This evidence concerns the gene KRAS and neoplasm.