Furthermore, Pentimalli et al. (54) described the presence of a niche rich in cytotoxic T cells, regulatory DCs, and Tregs, marked by localized expression of CXCL9, similar to our observations, as well as CCL19 and CCL21, in three-dimensional spatial transcriptomics analysis of a patient with high-grade NSCLC. Here, CCL21 is linked to non-small cell lung carcinoma.