Not only did the concentration of communities such as 10 and 18 to the interface and normal regions become less pronounced, but also spatial patterns within the tumor bulk changed following KRAS-G12C inhibition, as the frequency of many communities, such as 2 (type 2 macrophage dominant), 3 (tumor dominant), and 16 (mixed phenotype with high type 2 macrophage portion) was altered, suggesting a transition to a new organization of the TME (Fig. 2B and fig. This evidence concerns the gene KRAS and neoplasm.