Instead, in the MRTX849 + anti–PD-1 + anti–CTLA-4 tumors, CD8 T cells were mostly found within the tumor (“T/Tum” and “T/M2”) or in the normal adjacent tissue (“T/NA”) (Fig. 8, E and G), while still interacting with CD4 T cells and CD103+ DCs (Fig. 8E and fig. The gene discussed is CD8A; the disease is neoplasm.