In 2014, Zhumei Shi et al. verified that miR-124 directly targets R-Ras (related Ras viral oncogene homolog) and N-Ras(neuroblastoma Ras viral oncogene homolog), and also inhibits the Akt and Raf/ERK1/2 signaling pathways and mentioned miR-124 downregulation in glioma tissue [18]. This evidence concerns the gene MAPK3 and central nervous system cancer.