Fra-2 belongs to AP-1 transcription factor family and is related to cell-cycle drivers(Cyclin D1 and Cyclin E1), an invasion-associated gene (MMP9), the mesenchymal marker (Vimentin), and the induction of the epithelial marker (E-cadherin), ultimately inhibiting the proliferation, migration, invasion, and tumorigenicity of glioma cells [12]. Here, MMP9 is linked to central nervous system cancer.