For instance, Wei-hua Zhao et al. displayed that miR-124 negatively regulates PPP1R13L (an inhibitory member of the apoptosis-stimulating protein of p53 family whit a role in growth, metastasis, and apoptosis) expression and also showed miR-124 is downregulated in glioma tissue [15]. This evidence concerns the gene TP53 and central nervous system cancer.