The inhibition of the phosphorylation of FOXO leads to its translocation from the nucleus to the cytoplasm, where it downregulates the expression of its target genes, promotes glycolysis, suppresses tumor necrosis factor–related apoptosis–inducing ligand (TRAIL) expression, inhibits apoptosis in tumor cells, and facilitates tumor cell growth and proliferation [28]. This evidence concerns the gene TNFSF10 and neoplasm.