demonstrated the ability of 8i to significantly decrease the expression of proteins in the PI3K/AKT pathway, including AKT, S6 and eukaryotic translation initiation factor 4E (eIF4E)‐binding protein 1 (4EBP1), thereby further inhibiting protein and nucleotide expression in PCa cells. The gene discussed is AKT1; the disease is posterior cortical atrophy.