A total of 24 genes exhibited differential expression, with 15 (ALKBL1, ALKBL5, DNMT1, DNMT3B, IGF2BP1, IGF2BP2, METTL3, NSUN5, RBM15, RBM15B, WTAP, YBX1, YTHDC1, THDF 1 and THDF 3) exhibiting upregulation in individuals with AD, and 9 (ALKBL3, DNMT3A, FMR1, IGF2BP3, LRPPRC, NSUN3, RBMX, YTHDC2 and THDF 2) exhibiting downregulation compared to non-AD patients (Figure 2A). This evidence concerns the gene DNMT3A and Alzheimer disease.