SQSTM1 and Alzheimer disease: AD-type changes linked to BMAA exposure have also been reported in a subadult pregnant harbor porpoise, including intracellular and ghost tangles, granulovacuolar degeneration bodies (TDP-43+, Aβ+, and P62/SQSTM1+), and Hirano bodies in the hippocampus, as well as Aβ+ plaques and intraneuronal staining in all brain regions [25].