Interestingly, a secreted protein related to Alzheimer ́s disease and AIS proteins EB1/3 [37, 38], the Activity-Dependent Neuroprotective Protein (ADNP), was downregulated (log2(FC) = – 0.40 and – log10(p-value) = 2.81). The gene discussed is ADNP; the disease is early-onset autosomal dominant Alzheimer disease.