As chemokine signatures and the expression patterns of chemokine receptors potentially have prognostic implications in MDS and AML (34, 35), we further evaluated the expression of the chemokine receptors C–C chemokine receptor 4 (CCR4), CCR6, CCR7 and C–X–C Motif Chemokine Receptor 3 (CXCR3), CD161, and CD294 within the T cell clusters (Supplementary Fig. S6). The gene discussed is CCR4; the disease is acute myeloid leukemia.