Likely, other factors co-act with TGFβ in the modulation of fibroblast phenotypic skew and microenvironment modulation in cancer, as also highlighted by the presence of other CAF-centric networks, including periostin (Supplementary Fig. S5A and S5C) and thombospondin (Supplementary Fig. S5B and S5D). Here, POSTN is linked to cancer.