To allow for contextualization of the cellular patterning and transcriptional activity unique to malignant pancreatic tissues, we included samples of histologically normal pancreas and chronic pancreatitis, in addition to treatment-naïve tumors (untreated PDAC), and tumors from patients who received FOLFIRINOX-based NAT chemoradiotherapy (NAT-PDAC; Supplementary Table S1). Here, BRD2 is linked to chronic pancreatitis.