For example, in the proximal and i.t. regions, the number of CD8+ T cells in cluster 1 was greater than that in cluster 2, yet cluster 1 had fewer CD8+ T cells in the distal region, indicating that cluster 1, as the high-infiltrated cluster, had more T cells infiltrating into the core area of the tumor (Fig. 2E). Here, CD8A is linked to neoplasm.