HAVCR2 and colorectal cancer: To clarify the spatial and functional diversity of TILs in the colorectal TME, we performed multiplexed IHC to examine the exhaustion of TILs in the TME, the expression of PD-1 and T-cell immunoglobulin and mucin domain–containing protein 3 (TIM-3), which are major biomarkers of T-cell exhaustion, and least absolute shrinkage and selection operator method–Cox analyses of the correlation between colorectal cancer prognosis and TME features.