HLA-DRB1 and juvenile idiopathic arthritis: In addition to finding that HLA-DRB1*01 was a statistically significant predictor of therapeutically resistant disease in our sample, and considering the established role of HLA class II associated genes in the etiopathogenesis of JIA [3], our study aimed to explore how other HLA class II alleles are associated with disease forms requiring the rapid introduction of second-line therapies.