The role of GAL(1-15) was tested in a key endophenotype related to depression as reward-related and anhedonic behaviour using animal models in a non-operant test as sucrose preferent test and novelty suppressed feeding and female urine sniffing test and in an operant test as saccharine self-administration test (SSAT) [79] (Table 1). The gene discussed is GAL; the disease is major depressive disorder.