These modifications agree with our previous work in naïve animals [95] and confirm the crucial role of 5-HT1AR in the hippocampus in the GAL(1-15)-FLX interaction reinforcing our previous hypothesis: the existence of a trimeric GALR1/GALR2/5-HT1AR heteroreceptor complex in cortico-limbic areas where altered allosteric receptor-receptor interactions can develop an ability of the GALR1-GALR2 component to enhance the 5-HT1AR protomer signalling [92, 95, 105] and could be the critical point to understand the effects of FLX-GAL(1-15) interaction in the OBX animal depression model. This evidence concerns the gene GAL and major depressive disorder.