AKT1 and colorectal carcinoma: Furthermore, circEPB41L2 was downregulated in the CRC exosomes, which stimulated CRC cell proliferation but decreases apoptosis by suppressing miR-942-5p and improving the and PTEN/AKT signal pathway in vitro, while overexpression exo-circEPB41L2 certainly weakened tumor growth and reversely enhanced tumor growth in vivo [163].