In CRC, exo-circPACRGL upregulated in CRC cells and promoted CRC invasion, as well as differentiation of N1 to N2 neutrophils via miR-142-3p/miR-506-3p-TGF-β1 axis, which dramatically influenced and contributed to human CRC treatment [77]. The gene discussed is TGFB1; the disease is colorectal carcinoma.