MAPT and Alzheimer disease: We further profiled two other AD mouse models with additional pathologies (Fig. 4a, Extended Data Fig. 4a-e, Supplementary Table 1): (i) 3xTG, displaying both amyloid plaque and tau tangle pathologies27, and (ii) BiGenic (BiG) mice, generated by crossing 5xFAD with N40K transgenic mice recapitulating both amyloid pathology and the newly discovered U1 snRNP splicing dysfunction in AD45.