Interestingly, we found a number of proteins enriched in the autophagy/lysosome pathway with delayed turnover rates (Supplementary Table 24), such as Tmem106b, which has been identified as an aggregated filament protein in several neurodegenerative disorders including AD94-96, and genetically linked to frontotemporal lobar degeneration (FTLD)97. The gene discussed is TMEM106B; the disease is frontotemporal dementia.