The intermittent LIM group alone showed a decline in the pro-inflammatory PAI-1, which is implicated in both Alzheimer’s disease and memory decline [Independent samples t-test (t = 2.62, df = 22, p = 0.016); paired samples t-test in LIM group t = 3.82 df = 9, p = 0.004; See Figure 3C]. This evidence concerns the gene SERPINE1 and early-onset autosomal dominant Alzheimer disease.