The previous studies also found that ABCA7 SNPs were associated with brain amyloidosis (Apostolova et al., 2018), changes in gray matter density (Stage et al., 2016), and Braak staging, a measure of neurofibrillary tangle development, which is associated with cognitive decline (Lyssenko and Praticò, 2021). This evidence concerns the gene ABCA7 and Mental deterioration.