ABCA7 promotes the efflux of lipids from cells to apolipoproteins and can also regulate phagocytosis and modulate the processing of amyloid precursor protein to generate the AD Aβ peptide, which is considered an important link in the pathogenesis of AD (Jehle et al., 2006; Meurs et al., 2012; Sakae et al., 2016). This evidence concerns the gene APP and Alzheimer disease.