IL4 and Increased total eosinophil count: The airway inflammation in T2-high asthma is closely associated with cytokines from type 2 T helper cells (Th2), particularly interleukin-4 (IL-4), which leads to eosinophilia, excessive mucus production, bronchial hyperresponsiveness, and immunoglobulin E (IgE) production (León & Ballesteros-Tato, 2021).