GRIN2A and cancer: We then looked at the hub-driver genes identified in a previous study of CRC network analyses (Palaniappan, Ramar & Ramalingam, 2016), and found that GRIN2A and EIF2B5 were significantly differentially expressed in the cancer samples (adj.p-values ∼2.14e−37 and 2.32e−13, respectively).