MSH2 and hereditary nonpolyposis colon cancer: Some of these drivers include dietary concerns (Willett, 2005), physical inactivity, obesity (de Jong et al., 2005), alcohol and tobacco (Zisman et al., 2006), etc. Familial forms of colorectal cancer include (i) familial adenomatous polyposis (FAP) associated with mutations in the APC tumor suppressor gene (TSG) (Wilmink, 1997); and (ii) hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) associated with mutations in the DNA repair pathway genes, MSH2 and MLH1 (Haggar & Boushey, 2009).