Finally, the appearance of keywords such as “Tumor-Necrosis-Factor,” “Tyrosine Kinase-1,” and “Endoplasmic-Reticulum Stress” suggested potential roles for immune-inflammatory responses (Kim et al., 2017), signaling pathway abnormalities (Kim et al., 2017; Burke et al., 2016), and cellular stress responses (Redman et al., 2022) in preeclampsia’s pathogenesis, further emphasizing the complexity of this multifactorial disease involving widespread biological processes and molecular network imbalances (Burton et al., 2019). The gene discussed is TNF; the disease is preeclampsia.