Notably, increased placental and fetal lipoprotein-associated phospholipase A2 in GDM patients might offer protection against oxidative stress (Schliefsteiner et al., 2017), The upregulation of nuclear factor erythroid 2-related factor 2 and antioxidant enzymes in the GDM placenta could represent protective mechanisms against oxidative stress (Manoharan et al., 2019). The gene discussed is NFE2L2; the disease is gestational diabetes.