The loss of NADPH oxidase 4 (NOX4) in HCC induces MR in a nuclear factor erythroid 2-related factor 2 (Nrf2)/Myc-dependent manner, promoting tumor progression and making this tumor suppressor function a targeted therapy (Penuelas-Haro et al., 2023). The gene discussed is NOX4; the disease is hepatocellular carcinoma.