In osteosarcoma, clustering of lactic acid metabolism could identify the NADH dehydrogenase (ubiquinone) complex I assembly factor 6 (NDUFAF6, also known as C8ORF38) gene, which is a lactic acid metabolism-related gene and a prognostic marker, thus making this gene a functional target for individuals with this cancer type (Wang et al., 2024a). This evidence concerns the gene NDUFAF6 and osteosarcoma.