NFKB1 and rheumatoid arthritis: SI can regulate the production of inflammatory cytokines (TNF-α, IL-6 and IL-1) by targeting immune cells such as T cells, macrophages, and neutrophils, thereby impacting various pathways including the NF-κB pathway, PI3K-Akt signaling pathway, toll-like receptor signaling pathway, chemokine signaling pathway, Jak-STAT signaling pathway, and nod-like receptor signaling pathway, ultimately exerting an anti-RA effect.