Indeed, the conceptof CKD–mineral and bone disorder (CKD–MBD) appeared in the early 2000s,emphasizing the key role of kidney disease and the accompanying abnormalities incalcium, phosphate, hormonal (PTH), vitamin (D), and bone metabolism on theappearance of calcifications in the vessels [15]. This evidence concerns the gene PTH and Marchiafava-Bignami disease.