HSP70 is protective inanti-apoptosis as it acts on different links of the apoptosis signaling pathway.Upregulation of HSP70 can promote Bcl-2 expression, reduce Bax expression, andincrease the ratio of Bcl-2/Bax, thereby inhibiting cardiomyocyte apoptosis anddelaying cardiac hypertrophy [43]. Here, BAX is linked to cardiac hypertrophy.