Stimulation of thecGAS–STING pathway subsequently activates the NLRP3/caspase-1/GSDMD-mediatedpyroptotic pathway, contributing to advancing diabetic cardiomyopathy [60].Targeted NLRP3 inhibition and gene silencing blocks caspase-1-dependentpyroptosis in cardiomyocytes and alleviated manifestations of cardiac hypertrophy[61]. Here, CASP1 is linked to diabetic cardiomyopathy.