This differential expression highlights its specific regulatoryrole in fibrosis-associated gene expression between these cell types [70].Moreover, RUNX2 deficiency has been observed to exacerbate kidney fibrosis inmodels of ureteral obstruction by enhancing TGFβ signaling, suggesting apotential protective role of RUNX2 against fibrosis through modulation of thispathway [71]. This evidence concerns the gene RUNX2 and Ureteral obstruction.