In their second study, biomarkerscores of four CS proteins (beta-2-microglobulin, aldolase B enzyme (ALDOB), liver-type fatty acid-binding protein (L-FABP), SerpinG1) andCLIP (Cystatin C, Lactate, IL-6, NT-proBNP) scores were developed to captureorgan dysfunction and changes in metabolism to identify high-risk patients foracute CS; however, the scores did not change during the acute phase of CS and LVunloading [43]. The gene discussed is FABP1; the disease is Cowden syndrome 1.