Furthermore, exercise boostedadenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1)/recombinant forkheadbox protein O3 (FOXO3) pathway protein expression when combined with theDIKTNKPVIF (DF) peptide to reduce hypertension in SHR [73]. The gene discussed is SIRT1; the disease is Hypertension.