Vascular remodeling and cardiac hypertrophyare primarily brought on by T helper cell 17 (Th17) cell and Treg cell imbalance, according to thestudy by Imiela et al. [44], which described a link between CD4+ Tcell imbalance and other factors, including hypertension and target organ damage.According to recent studies, Th17 cells, a crucial component of effector T cells,may also increase blood pressure [45, 46]. Here, CD4 is linked to hypertensive disorder.