CD8A and hypertensive disorder: However, according to a study by Lu et al. [37], prehypertensive cytokinesgenerated from CD8+ T cells may be a major contributor to hypertension.CD8+ T cells mature and secrete interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), leadingto increased inflammatory response, another way of inducing hypertension[37].