REN and hypertensive disorder: In addition to uncovering the connection between the transient activation of the sympathetic nervous system (SNS), the renin-angiotensin-aldosterone system (RAAS), and the dysregulation of vasoactive substances with the progression of hypertension, Navaneethabalakrishnan S and colleagues have demonstrated the escalating significance of immune cells in the pathogenesis of hypertension [6].