ANK1 and early-onset autosomal dominant Alzheimer disease: These changes in DNA methylation processes may serve as one of the contributing factors to Alzheimer’s disease, as they are suspected to disrupt specific genomic regions, such as ankyrin 1 (ANK1) or 5hmC, which are associated with the onset of Alzheimer’s disease (Lunnon et al., 2014; De Jager et al., 2014; Zhao et al., 2017).