In recent years, molecular biomarkers, including vascular endothelial growth factor (VEGF), coronin-like actin-binding protein 1C (CORO1C), epithelial cadherin (E-cadherin), and Ring Finger Protein 180 (RFP 180), have emerged as a prominent area of research in the context of GC LNM. The gene discussed is RNF180; the disease is gastric cancer.