LGALS3 and diabetes mellitus: Considering that gal-3 is a modulator of cell adhesion, migration, proliferation, and apoptosis and that it was previously related to the pathogenesis of type 1 diabetes, we investigated if gal-3 distribution in the NOD mouse thymus, especially in the giant PVS, could somehow interfere with the exit of mature thymocytes to the periphery, such as FoxP3+CD4+ T cells, favoring autoimmune reactions and diabetes.