TOP2A and cervical cancer: Studies involving HPV-16 and HPV-18 gene expression in cancers of the cervix affected by HPV 16 and 18 show that CDKN2/p16INK4A of the minichromosome maintenance (MCM) gene family and TOP2A are up-regulated in cancer cervix along with the increased expression of proteins of HPV E6/E7 genes [4].