PLAU and cancer: Plasminogen activator, urokinase (PLAU) and cyclophilin A (PPIA), which promote EMT in tumor cells and fibrosis in CAFs34–36, were enriched in signaling nodes between myCAFs:cancer cells and monocyte/macrophages:cancer cells in the older cohort (Fig. 5a, b), supporting the EMT ARPs previously observed (Fig. 3).