DNMT3A and myelodysplastic syndrome: Additionally, in spite of many years of study, it is still not clear how mutations in DNA methyltransferase 3A (DNMT3A) can lead to clonal hematopoiesis of indeterminate potential (CHIP)41, myelodysplastic syndrome (MDS)42,43 and Acute Myeloid Leukemia (AML)44,45.