As MUC15 dysregulation is context-dependent in disease (e.g. lower expression in prostate and hepatocellular metastatic cancers, and overexpression in renal carcinomas and preeclampsia), we sought to determine if MUC15 downregulation was sufficient to activate both p38α MAPK signaling and enhanced migration in HGSC. The gene discussed is MUC15; the disease is preeclampsia.