Importantly, we found that mRSS improvement mirrored decreases in telangiectasia, perivascular CD3+, and % CD8 + among CD3 + cells, while Fibrosis Score changes were associated with hyalinized collagen, subcutaneous fat loss, thickened intima, and eccrine entrapment during belumosudil treatment. Here, CD8A is linked to telangiectasis.