Belumosudil downregulates proinflammatory responses by inhibiting signal transducer and activator of transcription 3 (STAT3) phosphorylation, upregulating STAT5 phosphorylation, and shifting T helper 17 (Th17)/T regulatory (Treg) balance towards the Treg phenotype: all mechanisms that have been implicated in SSc skin disease [28]. The gene discussed is STAT3; the disease is systemic sclerosis.