TRAE grade 3 or higher were anemia (7%), hyperbilirubinemia (7%), acute hepatic failure 3%, increased AST (3%), increased ALT (3%), increased gamma-glutamyltransferase (3%), thrombocytopenia (3%), hypoxia (3%), and stomatitis (3%) (Table 3). The gene discussed is GPT; the disease is Acute hepatic failure.