Increased plasma CXCL12 levels have previously been associated with an increased risk of CAD in the general population.51 Despite the systemic increase in CXCL12, local production of CXCL12, such as by arterial endothelial cells, is thought to be pro-atherogenic.52 In our study, we observed higher levels of CXCL12 expression in the atheroma of PLWH compared to PWoH, predicted to be expressed by fibroblasts. This evidence concerns the gene CXCL12 and coronary artery disorder.