CRP and depressive symptom measurement: At 24 months, all patients in the cohort experienced at least one AE. Common AEs and their respective percentages included headache related to surgical procedures (88.9%), nausea (33.3%), depression (22.2%), muscle spasticity (22.2%), vomiting (22.2%), increased blood glucose (16.7%), elevated C-reactive protein levels (16.7%), constipation (16.7%), fatigue (16.7%), pain in extremity (16.7%), and urinary tract infection (16.7%). Most of these AEs were mild (11.1%) or moderate (50.0%) in intensity.