Surgical exploration uncovered an 8 cm firm, irregular intra-axial lesion, which was resected, and a biopsy was obtained for histopathological evaluation; hematoxylin and eosin (H/E) staining revealed features suggestive of a metastatic large-cell neuroendocrine carcinoma (Figure 2), confirmed by synaptophysin (Figure 3) and chromogranin (Figure 4) immunohistochemistry (IHC) stains. Following the procedure, the patient received intensive care unit (ICU) management and remained asymptomatic without deterioration for one week. This evidence concerns the gene SYP and large cell neuroendocrine carcinoma.