Steroid treatments, including cortisol and thyroid hormones, have also been explored for CFS/ME [40]. Seven randomized controlled trials (RCTs) have been conducted: four involving hydrocortisone, two with fludrocortisone, and one trial combining hydrocortisone and fludrocortisone [1]. This evidence concerns the gene TG and myalgic encephalomeyelitis/chronic fatigue syndrome.